A study conducted by a group of scientists from the University of Michigan Medical School led by Dr Dana Sachs indicated that the cancer-fighting cream, fluorouracil, reverses changes associated with the ageing effects of too much sun, including fine and deep wrinkles, dark spots, shadows and sallowness. The cream improved the skin by initially damaging it. A period of irritation and inflammation was followed by a healing response which effectively “rebuilt” the outer layers of skin on the face.